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Doctors are reporting the first evidence that genetically edited cells could offer a safe way to treat sickle cell disease, a devastating, incurable disorder that afflicts millions of people around the world.

Billions of cells that were genetically modified with the powerful gene-editing technique called CRISPR have started working, as doctors had hoped, inside the body of the first sickle cell patient to receive the experimental treatment, according to highly anticipated data released Tuesday.

In most states, prosecutors can file murder charges if someone dies during a crime — even if the death is accidental. Juvenile justice groups say that is unfair and want the laws changed.

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Good morning. I'm David Greene. Her parents are award-winning artists, and now she is, too. Blue Ivy, the 7-year-old daughter of Beyonce and Jay-Z, has won a songwriting award for the hit "Brown Skin Girl."

(SOUNDBITE OF SONG, "BROWN SKIN GIRL")

A New Chapter For Sudan

Nov 19, 2019

Editor's note: This is an excerpt of Planet Money's newsletter. You can sign up here.

Sudan is in the midst of massive change. In September, a new 18-member cabinet took the official oath of office, a milestone for the historic joint civilian-military council. And now, as ousted former President Omar al-Bashir awaits trial for corruption, Sudan is beginning to rebuild itself. It just announced a nine-month economic rescue plan.

Updated at 1 p.m. ET

Two western hostages held for more than three years by Taliban forces in Afghanistan were freed today in southeastern Zabul province in exchange for three Taliban commanders held by the Kabul government, an Afghan official tells NPR's Diaa Hadid. The official requested anonymity because he is not authorized to speak to the news media.

The Democratic presidential primary has taken a back seat to the impeachment inquiry over the past few months, so it's fitting that the fifth candidate debate will take place on the same day that the most anticipated impeachment witness, Ambassador to the EU Gordon Sondland, testifies before the House Intelligence Committee.

But a lot more than the path to impeachment has changed since the Democratic candidates last gathered on the debate stage.

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Iran's government is struggling to shut down widespread protests that started after a rise in fuel prices.

(SOUNDBITE OF PROTEST)

UNIDENTIFIED PROTESTERS: (Chanting in foreign language).

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Updated at 8:40 p.m ET

Two witnesses called by Republicans in the House impeachment inquiry testified Tuesday, indicating they had reservations over the content of President Trump's July 25th phone call with the president of Ukraine, and his desire to investigate former Vice President Joe Biden.

The country is witnessing one of only a handful of times in its history that Congress has gone through with public hearings on whether to impeach a president. And yet, the overwhelming majority of Americans across parties say nothing they hear in the inquiry will change their minds on impeachment, according to a new NPR/PBS NewsHour/Marist poll.

Senior White House adviser Stephen Miller is an immigration hard-liner. He engineered the Trump administration's family-separation policy and its travel ban on people from some Muslim-majority countries.

Updated at 9:02 p.m. ET

Secretary of State Mike Pompeo announced Monday the Trump administration's latest pro-Israel change in U.S. policy, saying the State Department is rescinding a 1978 department legal opinion that viewed settlements in the Israeli-occupied West Bank as inconsistent with international law.

The Trump administration's plan to ban most flavored vaping products has stalled out, at least for the moment.

Two months ago, President Trump announced he was pursuing the new policy to put a dent in the youth vaping epidemic. The plan was supposed to have been unveiled in a matter of weeks.

But industry pushback and the politics of vaping appear to have derailed that process.

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Susannah Cahalan had all the symptoms of a severe mental illness.

SUSANNAH CAHALAN: I was hallucinating. I was paranoid. I was actively psychotic.

The Italian city of Venice is still reeling from a week of three exceptional tides whose floodwaters have caused massive damage to the city's cultural legacy and to residences and businesses.

The disaster has gripped Italy and inspired a wave of volunteers to salvage what they can.

There is a bookshop in Campiello del Tintor square named Libreria Acqua Alta, which means High Water Bookstore. Following Sunday's exceptional high tide, the square as well as the store's pavement were under several inches of water.

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The Samoan government closed schools indefinitely Monday as it attempts to quell a measles epidemic that has killed at least six people and hospitalized dozens more. Health officials said the Pacific island nation's low immunization rate is the cause of the outbreak.

Posted on Nov. 20 at 5:15 p.m. ET

An updated report about the study and the author's error has been posted here.

Posted on Nov. 19 at 6:53 p.m. ET

We have withdrawn this story about U.S. incarceration rates of children because the U.N. study's author has acknowledged a significant error in the data. We will post a revised article with more complete information as soon as possible.

House lawmakers have introduced a temporary funding measure to thwart another government shutdown, with hopes to move the legislation to the Senate and the president's desk before federal agencies run out of money at midnight on Thursday.

The legislative measure, known as a continuing resolution, or CR, will fund the government through Dec. 20. This would mark the second continuing resolution to take effect since the fiscal year began Oct. 1.

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We're going way up north for our next story to a ship in the middle of the Arctic Ocean. The scientists aboard are there to do fieldwork, which is easier said than done, as Ravenna Koenig reports.

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